Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig

Autor:	J D McGivan, Chris Haley, Alan Archibald, T M Skinner, E Doran
Rok vydání:	2005
Předmět:	Genetics education.field_of_study Boar taint Sequence analysis Population Single-nucleotide polymorphism General Medicine Quantitative trait locus Biology Molecular biology chemistry.chemical_compound Domestic pig CYP2E1 Gene chemistry Animal Science and Zoology Skatole education
Zdroj:	Animal Genetics. 36:417-422
ISSN:	1365-2052 0268-9146
DOI:	10.1111/j.1365-2052.2005.01342.x
Popis:	The porcine cytochrome-p450 2E1 (CYP2E1) gene was isolated by screening a pig BAC library and partially sequenced. This sequence information was used to identify six single nucleotide polymorphisms (SNPs) within the CYP2E1 gene and its promoter. In addition, a microsatellite marker tightly linked to the CYP2E1 gene was subcloned from the BAC. One of these markers was used to map the CYP2E1 gene distal of SWC27 on SSC14, well outside reported quantitative trait loci on SSC14 for skatole, indole and taste test measures of boar taint. However, in a population of commercial pigs scored for backfat skatole levels, there was evidence of association between a SNP in the CYP2E1 promoter and skatole deposition, although there was no significant association between this SNP and skatole levels in the experimental cross.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::abe13f7ca3b3b57cd6f898e6fb6f7462 https://doi.org/10.1111/j.1365-2052.2005.01342.x Zobrazit plný text záznamu Plný text ve formátu PDF