Epidemiological features of nosocomial Klebsiella pneumoniae: virulence and resistance determinants

Autor:	Mai M Zafer, Maha M El Bastawisie, Mona Wassef, Amira FA Hussein, Mohammed A Ramadan
Rok vydání:	2022
Předmět:	Microbiology (medical) polycyclic compounds biochemical phenomena metabolism and nutrition Microbiology
Zdroj:	Future Microbiology. 17:27-40
ISSN:	1746-0921 1746-0913
Popis:	Aim: The authors aimed to examine antibiotic resistance genes and representative virulence determinants among 100 Klebsiella pneumoniae isolates with an emphasis on capsular serotypes and clonality of some of the isolates. Methods: PCR amplification of ( rmpA, rmpA2, iutA, iroN and IncHI1B plasmid) and (NDM, OXA-48, KPC, CTX-M-15, VIM, IMP, SPM) was conducted. Wzi sequencing and multilocus sequence typing (MLST) were performed. Results: K2 was the only detected serotype in the authors' collection. RMPA2 was the most common capsule-associated virulence gene detected. All studied isolates harbored OXA-48-like (100%) and NDM (43%) (n = 43). ST147 was the most common sequence type. Conclusion: This work provides insight into the evolution of the coexistence of virulence and resistance genes in a tertiary healthcare setting in Cairo, Egypt.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::abb80b1328226874b7cf312a53ea7da6 https://doi.org/10.2217/fmb-2021-0092 Zobrazit plný text záznamu