Inhibitory Effect of Perilla frutescens L. Leaves Extract on Melanogenesis and Skin Whitening Efficacy in the Underarm Whitening Product Application
| Autor: | Nattapol Aunsri, Pattavet Vivattanaseth, Lapatrada Mungmai, Payungsak Tantipaiboonwong, Weeraya Preedalikit, Komsak Pintha |
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| Rok vydání: | 2020 |
| Předmět: |
Perilla frutescens
integumentary system biology Traditional medicine Chemistry Mechanical Engineering Skin whitening 04 agricultural and veterinary sciences biology.organism_classification 040401 food science 030207 dermatology & venereal diseases 03 medical and health sciences 0404 agricultural biotechnology 0302 clinical medicine Mechanics of Materials Product (mathematics) General Materials Science Inhibitory effect |
| Zdroj: | Key Engineering Materials. 859:166-171 |
| ISSN: | 1662-9795 |
| Popis: | The effect of Perilla frutescens L. leaves extract (PFLE) on melanogenesis regulation in B16F10 cells was investigated. The extract had a significant inhibitory effect on melanogenesis in a dose-dependent manner without cytotoxicity at concentrations between 2.5 and 10 μg/mL. The PFLE was formulated as an underarm serum (PL serum) and evaluated for skin irritation and its skin whitening efficacy on 30 Thai women twice daily for 4 weeks. Changes in skin melanin and erythema index, L* a* values were studied. A gradual decrease in melanin index from 37.94±0.66 to 35.90±0.64 (5.38%), and a significant decrease in erythema index from 11.32±0.79 to 10.21±0.11 (9.80%) could be observed during a 4-week period. Therefore, the efficacy of PL serum in improving skin was demonstrated by a significant decrease in melanin and erythema index compared with initial values and skin tone was improved without skin irritation. Extract from Perilla frutescens L. leaves can be used as a novel whitening cosmeceutical ingredient. |
| Databáze: | OpenAIRE |
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