The potential of using the bioluminescent system of Chaetopterus variopedatus to study ferroptosis in living organisms

Autor:	AS Shcheglov As, AS Tsarkova
Rok vydání:	2021
Předmět:	0301 basic medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine biology Chemistry 030220 oncology & carcinogenesis Ferroptosis Bioluminescence General Medicine Chaetopterus variopedatus biology.organism_classification Cell biology
Zdroj:	Bulletin of Russian State Medical University.
ISSN:	2542-1204 2500-1094
DOI:	10.24075/brsmu.2021.024
Popis:	Ferroptosis is a form of programmed cell death associated with iron-dependent lipid peroxidation. Novel ferroptosis inducers and suppressors could be instrumental in developing drugs against neurodegenerative disorders and cancer. Prior to embarking on a search for ferroptosis inducers/suppressors, this form of cell death must be studied in living cells and laboratory animals. In addition to two cofactors, luciferase (or photoprotein) of the parchment tubeworm Chaetopterus variopedatus requires the presence of iron ions and hydrogen peroxide or organic hydroperoxides to exert its activity. Therefore, the bioluminescence system of the parchment tubeworm can be used to study ferroptosis in living organisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ab71dbe790cd151ec868b54b3b88fb9a https://doi.org/10.24075/brsmu.2021.024 Zobrazit plný text záznamu