Circulating Level of Soluble Leptin Receptor and its Association with Cardiometabolic Risk Factors among Obese Subjects in Kerala, South India
| Autor: | K. S. Manju, K. B. Leena, L. Vijayalekshmi, K. T. Shenoy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Leptin receptor business.industry Insulin medicine.medical_treatment Leptin Adipose tissue medicine.disease Obesity Body fat percentage Waist–hip ratio Endocrinology Insulin resistance Internal medicine medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Pharmaceutical Research International. :232-239 |
| ISSN: | 2456-9119 |
| Popis: | Background and Aims: Leptin, the peptide hormone secreted mainly by adipose tissue is reported to play the central role in the pathogenesis of obesity. Leptin exerts its biological effects through specific receptor molecules present in target tissues. Among the different isoforms of leptin receptor, the Soluble Leptin Receptor (SLR) is the major leptin binding protein seen in circulation which modulates the bioavailability of leptin. Our objectives were to analyse the level of circulating SLR among obese subjects and its association with biomarkers of obesity, serum leptin, insulin and cardiometabolic risk factors in comparison with healthy age and sex matched control subjects. Methods: About 173 study participants of both genders were selected and grouped as case (n=102) and control (n=71) with a cut off point of BMI 25kg/m2. Waist to hip ratio (WHR) and body fat percentage (BF%) were calculated from anthropometric measurements. Leptin, insulin, soluble leptin receptor were estimated in fasting blood samples by sandwich ELISA method. Fasting plasma glucose and lipid profile were measured by standard enzymatic methods in autoanalyzer. Homeostasis Model Assessment of Insulin resistance (HOMA-IR) was calculated. Comparison between groups was done by independent sample ‘t’ test. P values |
| Databáze: | OpenAIRE |
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