Synthesis of (.+-.)-carba-analogs of 5-HPETE and leukotriene A4,unstable intermediates of slow-reacting substance (SRS)

Autor:	Katsuichi Shimoji, Mitoshi Konno, Masaaki Toda, Y. Arai, Masaki Hayashi, Haruki Niwa, Yoshitaka Konishi
Rok vydání:	1982
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Leukotriene A4 Drug Discovery 5-Lipoxygenase Inhibitor General Chemistry General Medicine
Zdroj:	Chemical and Pharmaceutical Bulletin. 30:379-382
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.30.379
Popis:	The carba-analogs of 5-HPETE and leukotriene A4, unstable intermediates of slow-reacting substance (SRS), were synthesized. These carbaanalogs inhibited the 5-lipoxygenase. The carba-analog of leukotriene A4 was a particularly potent specific inhibitor of the 5-lipoxygenase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ab2763c93a517f6727190b45ca8a438a https://doi.org/10.1248/cpb.30.379 Zobrazit plný text záznamu