Resting and post-exercise serum biomarkers of cardiac and skeletal muscle damage in adolescent runners
| Autor: | Tom K K Tong, Qingde Shi, Frank H K Fu, Hua Lin, Jinlei Nie, Keith George |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
biology business.industry Skeletal muscle Physical Therapy Sports Therapy and Rehabilitation Troponin chemistry.chemical_compound Endocrinology medicine.anatomical_structure Troponin complex chemistry Serum biomarkers Internal medicine Lactate dehydrogenase Troponin I biology.protein Medicine Orthopedics and Sports Medicine Creatine kinase Skeletal muscle damage business |
| Zdroj: | Scandinavian Journal of Medicine & Science in Sports. 21:625-629 |
| ISSN: | 0905-7188 |
| DOI: | 10.1111/j.1600-0838.2010.01096.x |
| Popis: | This study examined the response of serum biomarkers of cardiac and skeletal muscle damage at rest and after a routine workout of 21 km run in 12 male adolescent (16.2±0.6 years) long-distance runners. Biomarkers of cardiac [troponins (cTnT, cTnI), creatine kinase MB mass (CK-Mbmass)] and skeletal muscle [creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and hydroxybutyrate dehydrogenase (HBD)] damage were assayed at rest, 2, 4 and 24 h post-exercise. At rest, cTnT and cTnI were not detectable; however, CK, CK-MBmass, AST, ALT and HBD were above corresponding clinical cut-off values. Post-exercise significant elevations above rest were observed for all biomarkers, except ALT, 2 and 4 h following the run, and remained elevated in cTnI, CK, CK-MBmass, LDH and AST 24 h post-workout. A significant increase in data points above clinical cut-off values from rest to post-exercise was reported for cTnT, cTnI and CK at 2 and 4 h, and in cTnI and CK 24 h post-exercise. In conclusion, a 21 km run in adolescent runners increased post-exercise biomarkers of cardiac and skeletal muscle damage. |
| Databáze: | OpenAIRE |
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