ChemInform Abstract: The Chemical Development of the Commercial Route to Sildenafil: A Case History

Autor:	Peter J. Dunn, Albert Shaw Wood, Gordon Ward, Clare Golightly, Hughes Michael Leslie, Andrew K. Pearce, David J. Dale, Patricia M. Searle, Philip Charles Levett
Rok vydání:	2010
Předmět:	Process safety Chemistry Decarboxylation General Medicine Combinatorial chemistry
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200015242
Popis:	This paper is a case history of the chemical development of sildenafil which covers various aspects of work in chemical development namely: route selection, scale-up issues, the development of an efficient synthesis with high throughput, process safety, and environmental issues. Interesting chemical points include improved methods of preparing pyrazolo[4,3-d]pyrimidines and the unusual isolation of an intermediate as its double salt (10). The potential dangers of nitrating pyrazole-5-carboxylic acids which are activated to a decarboxylation reaction are discussed.
Databáze:	OpenAIRE
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