Effect and Action Mechanism of Prostaglandin E2 on Proliferation of Human Colon Cancer Cells in Culture

Autor:	Shinichi Nishimatsu, Daisuke Kuroda, Michio Kato, Harumasa Ohyanagi, Yoichi Saitoh, Hideaki Nomura, Yuichi Hori, Satoru Okumoto
Rok vydání:	1993
Předmět:	medicine.medical_specialty Colorectal cancer Cell growth Vasoactive intestinal peptide Cell Stimulation Metabolism Biology medicine.disease Endocrinology medicine.anatomical_structure Cell culture Internal medicine medicine lipids (amino acids peptides and proteins) Prostaglandin E2 medicine.drug
Zdroj:	Recent Advances in Management of Digestive Cancers ISBN: 9784431682547
DOI:	10.1007/978-4-431-68252-3_167
Popis:	The effect of prostaglandin E2(PGE2) on the growth of human colon cancer cell line HT-29 was investigated. PGE2 significantly inhibited the growth of HT-29 cells without increasing cyclicAMP production. Furthermore, the proliferation of HT-29 cell was not suppressed by the administration of vasoactive intestinal peptide or dibutyryl cyclicAMP. The metabolism of PGE2 in the culture medium showed that a considerable amount of PGA2 was produced from PGE2. These observations suggest that PGE2 inhibits the cell growth of HT-29 without stimulation of cAMP production, and that this inhibitory effect was due to the metabolic change of PGE2 to PGA2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aab3e12ee5fe84e5c4a06fe1d3a33699 https://doi.org/10.1007/978-4-431-68252-3_167 Zobrazit plný text záznamu