Circulating Sex Hormone Levels and Risk of Esophageal Adenocarcinoma in a Prospective Study in Men
| Autor: | Shao-Hua Xie, Fredrik Mattsson, Hilde Langseth, Randi Elin Gislefoss, Sirus Rabbani, Jesper Lagergren, Eivind Ness-Jensen |
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| Rok vydání: | 2019 |
| Předmět: |
Hepatology
biology business.industry Gastroenterology Case-control study Physiology Odds ratio Prolactin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dehydroepiandrosterone sulfate Sex hormone-binding globulin chemistry 030220 oncology & carcinogenesis biology.protein Medicine 030211 gastroenterology & hepatology Prospective cohort study business Luteinizing hormone Testosterone |
| Zdroj: | American Journal of Gastroenterology. 115:216-223 |
| ISSN: | 1572-0241 0002-9270 |
| DOI: | 10.14309/ajg.0000000000000446 |
| Popis: | Objectives Sex hormones have been hypothesized to explain the strong male predominance in esophageal adenocarcinoma, but evidence is needed. This study examined how circulating sex hormone levels influence future risk of esophageal adenocarcinoma. Methods This case-control study was nested in a prospective Norwegian cohort (Janus Serum Bank Cohort), including 244 male patients with esophageal adenocarcinoma and 244 male age-matched control participants. Associations between prediagnostic circulating levels of 12 sex hormones and risk of esophageal adenocarcinoma were assessed using conditional logistic regression. In addition, a random-effect meta-analysis combined these data with a similar prospective study for 5 sex hormones. Results Decreased odds ratios (ORs) of esophageal adenocarcinoma were found comparing the highest with lowest quartiles of testosterone (OR = 0.44, 95% confidence interval [CI] 0.22-0.88), testosterone:estradiol ratio (OR = 0.37, 95% CI 0.19-0.72), and luteinizing hormone (OR = 0.50, 95% CI 0.30-0.98), after adjustment for tobacco smoking and physical activity. These associations were attenuated after further adjustment for body mass index (OR = 0.56, 95% CI 0.27-1.13 for testosterone; OR = 0.46, 95% CI 0.23-0.91 for testosterone:estradiol ratio; OR = 0.55, 95% CI 0.29-1.08 for luteinizing hormone). No associations were observed for sex hormone-binding globulin, dehydroepiandrosterone sulfate, follicle-stimulating hormone, prolactin, 17-OH progesterone, progesterone, androstenedione, or free testosterone index. The meta-analysis showed an inverse association between testosterone levels and risk of esophageal adenocarcinoma (pooled OR for the highest vs lowest quartile = 0.60, 95% CI 0.38-0.97), whereas no associations were identified for androstenedione, sex hormone-binding globulin, estradiol, or testosterone:estradiol ratio. Discussion Higher circulating testosterone levels may decrease the risk of esophageal adenocarcinoma in men. |
| Databáze: | OpenAIRE |
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