Allergen challenge-induced acute exudation of IL-8, ECP and α2-macroglobulin in human rhinovirus-induced common colds
| Autor: | Camilla I. Svensson, Magnus Andersson, C. G. A. Persson, Margareta Linden, Lennart Greiff, Steven H. Myint |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Eosinophil cationic protein Exacerbation business.industry Common cold respiratory system Eosinophil medicine.disease_cause medicine.disease Allergen medicine.anatomical_structure Immunology otorhinolaryngologic diseases Medicine Nasal Lavage Nasal Lavage Fluid Rhinovirus business |
| Zdroj: | European Respiratory Journal. 13:41-47 |
| ISSN: | 0903-1936 |
| DOI: | 10.1183/09031936.99.13104199 |
| Popis: | Rhinovirus infections cause exacerbations of eosinophilic airway disease. The acute effects of allergen-challenge on nasal interleukin-8 (IL-8), eosinophil cationic protein (ECP), and alpha2-macroglobulin were examined in atopic subjects with common cold symptoms. Twenty-three patients with seasonal allergic rhinitis were inoculated with human rhinovirus 16 outside the pollen season. Diluent and allergen challenges, followed by nasal lavages, were carried out about 3 months before and 4 days after virus inoculation. Seventeen patients developed significant common cold symptoms with increased nasal lavage fluid levels of alpha2-macroglobulin, IL-8, and ECP at baseline (p |
| Databáze: | OpenAIRE |
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