Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors

Autor:	Karen Selbert, Timothy S. Chamberlain, David B. Reitz, Carol M. Koboldt, Horng-Chih Huang, Peter C. Isakson
Rok vydání:	1995
Předmět:	chemistry.chemical_classification biology Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Combinatorial chemistry Sulfonamide chemistry Drug Discovery biology.protein Molecular Medicine Cyclooxygenase Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:2377-2380
ISSN:	0960-894X
Popis:	Novel series of diaryl indenes and benzofurans have been shown to be potent and selective COX-2 inhibitors. A structure-activity relationship study suggests that the conversion of sulfones to sulfonamides affords potent, but slightly less selective COX-2 inhibitors, and that for benzofurans the 3-halo-4-methoxyphenyl sulfonamide analogs are more selective than the corresponding 4-fluorophenyl analog.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aa255af019c02cd704540e412b74ec35 https://doi.org/10.1016/0960-894x(95)00414-o Zobrazit plný text záznamu Full Text from ScienceDirect