Full synthesis and bioactivity evaluation of Tn-RC-529 derivative conjugates as self-adjuvanting cancer vaccines
| Autor: | Su Shiwei, Yuan Fang, Zhongqiu Liu, Guochao Liao, Menglan Yang, Leilei Ma, Qinghai Lian, Xiang Luo, Lingqiang Gao |
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| Rok vydání: | 2021 |
| Předmět: |
Antiserum
Chemistry Relationship analysis Tn antigen Cancer 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences 0104 chemical sciences Immune system Biochemistry Derivative (finance) Cancer cell medicine 0210 nano-technology Conjugate |
| Zdroj: | Chinese Chemical Letters. 32:3011-3014 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2021.03.046 |
| Popis: | A facile and efficient strategy was established for the construction of RC-529 and its derivatives. Four conjugates of RC-529 derivatives with Tn antigen were synthesized and all elicited strong and T cell-dependent immune responses in mice without requiring external adjuvants. In addition, all antisera induced by these conjugates could specifically recognize, bind to and kill Tn-overexpressing cancer cells. Thus, RC-529 shows promise as a useful platform for the development of new vaccine carriers with self-adjuvanting properties for the treatment of cancer. Moreover, preliminary structure-activity relationship analysis provides convincing support for further optimization of, and additional investigation into, RC-529. |
| Databáze: | OpenAIRE |
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