Unusual isomerization reaction of a platinum-dinucleotide compound

Autor:	Kenji Inagaki, Jan Reedijk, Akinori Nagai, Yoshinori Kidani, Maarten Alink
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Reaction mechanism Stereochemistry Guanine chemistry.chemical_element Inorganic Chemistry chemistry.chemical_compound chemistry Platinum binding Nucleotide Chelation Physical and Theoretical Chemistry Bifunctional Platinum Isomerization
Zdroj:	Inorganic Chemistry. 29:2183-2185
ISSN:	1520-510X 0020-1669
DOI:	10.1021/ic00336a031
Popis:	The reaction between a bifunctional platinum complex and nucleic acid base occurs via a two-step mechanism, and the first step is normally a preferential binding to the N7 site of a guanine. The present paper mainly describes results obtained about the second step, i.e., chelation after the first platinum binding. The reaction of [Pt,(R,R-dach)(OH 2 ) 2 ] 2+ with r(GpA) (abbreviations: R,R-dach, 1R,2R-cyclohexanediamine; r(GpA), guanylyl(3'-5')adenosine) results in interbase cross-linked compounds between the guanine and the adenine bases
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a8d2b415d6ea05cc798feb9079469fe9 https://doi.org/10.1021/ic00336a031 Zobrazit plný text záznamu