The structures of xenorine A–C from the entomopathogenic bacterium Xenorhabdus indica
| Autor: | Lie-Feng Ma, You-Min Ying, Jian-Biao Yao, Zha-Jun Zhan, Wei-Guang Shan, Wei-Wei Pang, Ling Fang, Yuan-Yuan Li, Hao-Ying Qian, Yang Zheng |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Xenorhabdus indica Natural product biology 010405 organic chemistry Stereochemistry Absolute configuration General Chemistry medicine.disease_cause biology.organism_classification 01 natural sciences In vitro 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Product (mathematics) medicine Density functional theory Two-dimensional nuclear magnetic resonance spectroscopy Bacteria |
| Zdroj: | Journal of Chemical Research. 41:262-265 |
| ISSN: | 2047-6507 1747-5198 |
| DOI: | 10.3184/174751917x14925986241016 |
| Popis: | Three new compounds, xenorine A-C, along with six known compounds were isolated from the cultured broth of Xenorhabdus indica. The chemical structures of these compounds were elucidated mainly by analysis of 1D and 2D NMR and MS data. The major metabolites were dioxopiperazines. In addition, 5,6,11,11a-tetrahydro-1 H-imidazo[1′,5′:1,6]pyrido[3,4- b]indole-1,3(2 H)-dione, previously described as synthetic product, was isolated as a natural product. The absolute configuration was determined using quantum chemical time-dependent density functional theory calculations. The six known compounds showed weak in vitro immunosuppressive activity towards concanavalin-A- and lipopolysaccharide -induced proliferation of mice splenocytes. |
| Databáze: | OpenAIRE |
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