'Clip' and 'Click' Chemistries Combination: Toward Easy PEGylation of Degradable Aliphatic Polyesters

Autor:	Cécile S. Le Duff, Vincent Pourcelle, Hélène Freichels, Christine Jérôme, Jacqueline Marchand-Brynaert
Rok vydání:	2011
Předmět:	Materials science Polymers and Plastics Organic Chemistry Cycloaddition Polyester chemistry.chemical_compound chemistry PEG ratio Amphiphile Photografting Materials Chemistry PEGylation Click chemistry Organic chemistry Ethylene glycol
Zdroj:	Macromolecular Rapid Communications. 32:616-621
ISSN:	1022-1336
DOI:	10.1002/marc.201000803
Popis:	a-Methoxy-v-alkyne poly(ethylene glycol) (PEG) was tagged with pendent N-hydroxy-succinimidyl activated esters by photografting of a molecular clip. This easily synthesized heterofunctional PEG was found to be a versatile building block for (i) conjugation with an amino derivative and (ii) grafting to azido functional aliphatic polyesters backbone by Huisgen’s 1,3- dipolar cycloaddition. This original combination of ‘‘clip’’ and ‘‘click’’ reactions provides a versatile and straightforward pathway for the synthesis of functional amphiphilic and degradable copolymers valuable for biomedical applications such as in drug-delivery.
Databáze:	OpenAIRE
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