The question of derepression ofH-2 specificities in virus-infected cells: Failure to detect specific alloreactive T cells after systemic virus infection or alloantigens detectable by alloreactive T cells on virus-infected target cells

Autor:	Brian Adler, Rolf M. Zinkernagel, A Althage
Rok vydání:	1977
Předmět:	Immunology chemical and pharmacologic phenomena Biology Lymphocytic choriomeningitis medicine.disease biology.organism_classification Virology Virus Interleukin 21 Immune system Antigen Vesicular stomatitis virus Genetics medicine Cytotoxic T cell Derepression
Zdroj:	Immunogenetics. 5:367-378
ISSN:	1432-1211 0093-7711
DOI:	10.1007/bf01570495
Popis:	Cultured cells of variousH-2 haplotypes were infected acutely with vaccinia, lymphocytic choriomeningitis, or vesicular stomatitis virus and tested for the appearance of newly expressed, unexpected alloantigens or the absence of expected antigens of variousH-2 haplotypes. No repression or derepression of unexpected alloantigens could be detected when such specificities were sought by using alloreactive cytotoxic T cells. Similarly, immune virus-specific cytotoxic T cells from various strains of mice with differentH-2 haplotypes did not lyse uninfectedH-2-incompatible target cells differentially in an alloantigen-specific fashion. Therefore, it seems unlikely that the H-2-restricted specificity of cytotoxic T cells generated in these acute virus infections can be explained by their being sensitized to derepressed H-2 antigens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7ce1c3f6594387a2c7ff7b63423adee https://doi.org/10.1007/bf01570495 Zobrazit plný text záznamu Full text from SpringerLink