| Autor: |
R. Angioni, M. Bonfanti, N. Caporale, R. Sánchez-Rodríguez, F. Munari, A. Savino, D. Buratto, I. Pagani, N. Bertoldi, C. Zanon, P. Ferrari, E. Ricciardelli, C. Putaggio, S. Ghezzi, F. Elli, L. Rotta, F. Iorio, F. Zonta, A. Cattelan, E. Vicenzi, B. Molon, C.E. Villa, A. Viola, G. Testa |
| Rok vydání: |
2022 |
| Popis: |
The spread of SARS-CoV-2 has fueled the COVID-19 pandemic with its enduring medical and socioeconomic challenges due to subsequent waves and long-term consequences of great concern. Here we charted the molecular basis of COVID-19 pathogenesis, by analysing patients’ immune response at single-cell resolution across disease course and severity. This approach uncovered cell subpopulation-specific dysregulation in COVID-19 across disease course and severity and identified a severity-associated activation of the receptor for advanced glycation endproduct (RAGE) pathway in monocytes. In vitro experiments confirmed that monocytes bind the SARS-CoV-2 S1-RBD via RAGE and that RAGE-Spike interactions drive monocyte infection. Our results demonstrate that RAGE is a novel functional receptor of SARS-CoV-2 contributing to COVID-19 severity.One-Sentence SummaryMonocyte SARS-CoV-2 infection via the receptor for advanced glycation endproduct triggers severe COVID-19. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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