Amino acid based bioanalogous polymers. Novel regular poly(ester urethane)s and poly(ester urea)s based on bis(L-phenylalanine) α,ω-alkylene diesters
| Autor: | Kartvelishvili Tamara M, George Tsitlanadze, Ramaz Katsarava, Nona N. Japaridze, Lamara Edilashvili |
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| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Condensation polymer Polymers and Plastics Chemistry Organic Chemistry Potentiometric titration Phenylalanine Condensed Matter Physics Amino acid Hydrolysis chemistry.chemical_compound Sulfonate Polymer chemistry Materials Chemistry Urea Physical and Theoretical Chemistry Triethylamine |
| Zdroj: | Macromolecular Chemistry and Physics. 198:1921-1932 |
| ISSN: | 1521-3935 1022-1352 |
| DOI: | 10.1002/macp.1997.021980620 |
| Popis: | Novel biodegradable regular poly(ester urethane)s 2 (η red ≤ 0,62 dL/g) were synthesized for the first time by polycondensation of di-p-toluenesulfonic acid salts of bis(phenylalanine) α,ω-alkylene diesters 1 with di-p-nitrophenyl trimethylenedicarbonate (4) under mild conditions in organic solvents in the presence of triethylamine as acid acceptor. The first synthesis of homopoly(ester urea)s 3 (q red ≤ 0,33 dL/g) was carried out by polycondensation of 1 with di-p-nitrophenyl carbonate (5) under the same conditions. Preliminary in vitro evaluation of specific and nonspecific hydrolysis of the polymers obtained has been brought about using potentiometric titration. |
| Databáze: | OpenAIRE |
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