Arthrophytum scopariumExtract Improves Memory Impairment and Affects Acetylcholinesterase Activity In Mice Brain
| Autor: | Khalifa Limem, Hedi Dridi, Med Ali Smach, Jawhar Hafsa, Ben A Jihene, Bassem Charfeddine |
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| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
business.industry Aché medicine.medical_treatment Intraperitoneal injection Pharmaceutical Science Glutathione Pharmacology Malondialdehyde Ascorbic acid 030226 pharmacology & pharmacy Acetylcholinesterase language.human_language 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry language Medicine Cholinergic business 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Current Pharmaceutical Biotechnology. 21:480-487 |
| ISSN: | 1389-2010 |
| Popis: | Background:Arthrophytum scoparium (Pomel) Iljin (Amaranthaceae family) has been widely used in traditional Tunisian medicine to treat many disorders such as migraine, headache, and neurological disorders. This study investigates the effect of Arthrophytum scoparium Aqueous Extract (ASAE) on cognitive impairments and oxidative injury induced by galactose (10%) in a mouse model.Materials and Methods:The mice were divided randomly into 4 experimental groups, including the control group (saline water 9 ‰), Galactose group, Scop group (300 mg/kg/d), and Scop+Gal group (300 mg/kg/d). Mice received the corresponding solutions by intraperitoneal injection (i.p.) for 7 days before the Y-maze active tests. Galactose 10% was given to all groups except control and Scop groups, 30 min before the trial. Levels of Acetylcholinesterase Activity (AChE), Ascorbic Acid (AA), Gluthatione (GSH) and Malondialdehyde (MDA) in mice brains were examined.Results:Chronic administration of galactose significantly impaired cognitive performance in Y maze, caused marked oxidative damages and a significant increase in the acetylcholinesterase activity as compared to other groups. On the contrary, ASAE (300 mg/kg) treatment suppressed galactoseinduced oxidative damage by ameliorating the increased levels of GSH and AA. Moreover, ASAE treatment reduced brain AChE activities in the galactose-induced model.Conclusion:These findings suggest that ASAE exerts potent anti-amnesic effects via the modulation of cholinergic and antioxidant activities. The observed pharmacological activities should be further evaluated by detailed experimental studies and validated by clinical trials. |
| Databáze: | OpenAIRE |
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