Sampling the Rat Mesenteric Artery
| Autor: | Marcia E. Pereira Bacares |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty 040301 veterinary sciences business.industry 04 agricultural and veterinary sciences Cell Biology Toxicology 030226 pharmacology & pharmacy Rats sprague dawley Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Pharmacologic effects Medicine Sampling (medicine) business Mesentery Molecular Biology Mesenteric arteries Artery |
| Zdroj: | Toxicologic Pathology. 44:1166-1169 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/0192623316667245 |
| Popis: | Vascular injury can be induced by different classes of drug candidates, and it can affect the mesenteric vasculature. Sampling of the mesenteric vessels in the rat is crucial for proper assessment of potential adverse or pharmacologic effects of drugs in nonclinical rodent studies. To date, several sampling and processing techniques for the histopathologic evaluation of the mesenteric artery in rodents have been described and used in studies with candidate drugs that may affect the vascular system. However, most of those techniques require a significant amount of time and effort. A less labor-intensive, time-consuming, and expensive technique that allows examination of the mesentery vasculature with abundant longitudinal and cross sections of the vessels when examined microscopically was developed and presented here. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|