The rhubarb total free anthraquinone oral colon-specific drug delivery granules: Comparative pharmacokinetics study with rhubarb by UPLC-MS/MS after oral administration
| Autor: | Pei Liu, Liyan Liu, Xigang Liu, Li Zhongsi, Jinhua Chang, Xiaodong Gu, Qiang Fu, Guangxin Miao, Cuizhe Liu, Lin Zhang, Xue Hefei |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmaceutical Science
02 engineering and technology Pharmacology 021001 nanoscience & nanotechnology High-performance liquid chromatography Anthraquinone Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Pharmacokinetics Oral administration 030220 oncology & carcinogenesis Drug delivery Anthraquinones Emodin 0210 nano-technology |
| Zdroj: | Journal of Drug Delivery Science and Technology. 43:415-422 |
| ISSN: | 1773-2247 |
| Popis: | Objective This study aimed to compare pharmacokinetics of rhubarb total free anthraquinones (AQs) oral colon-specific delivery granules (RTFA-OCDD-GN) and rhubarb after oral administration to evaluate the colonic-target releasing characteristic of RTFA-OCDD-GN and the impact of five AQs components on the contribution of the attenuation of nephrotoxicity. Methods The compare pharmacokinetics of RTFA-OCDD-GN and rhubarb was performed in rats. The plasma concentrations of aloe-emodin, rhein, emodin, chrysophanol and physcion were assayed by a validated UPLC-MS/MS method. Results The pharmacokinetics results showed that the AUC0-72h of aloe-emodin, emodin, chrysophanol and physcion was decreased by 3.09-fold (p 0.05) compared with group rhubarb samples. However the dose-normalized AUC0-72h of aloe-emodin, rhein, emodin and chrysophanol was decreased by 1.90-fold (p Conclusion These differences on pharmacokinetic parameters indicated that RTFA-OCDD-GN delivered AQs to colon. The systemic exposure reduction of aloe-emodin, emodin and physcion in group RTFA-OCDD-GN could contribute to the attenuation of nephyrotoxicity caused by rhubarb. |
| Databáze: | OpenAIRE |
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