Isolation and Identification of α-Glucosidase Inhibitor From Aspergillus Terreus F38
| Autor: | Siti Munasaroh, Rizna Triana Dewi, Swasono R Tamat |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chromatography
biology 010405 organic chemistry Chemistry α glucosidase Pharmaceutical Science Pharmacy biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Postprandial Pharmacology (medical) Spectral analysis Fermentation Aspergillus terreus Lead compound Mycelium |
| Zdroj: | INDONESIAN JOURNAL OF PHARMACY. 29:74 |
| ISSN: | 2338-9486 2338-9427 |
| DOI: | 10.14499/indonesianjpharm29iss2pp74 |
| Popis: | Controlled postprandial glucose level is an important strategy in preventing DM type 2. Inhibitors of α-glucosidase have been postulated to be useful agents in managements of DM type 2. This research aims to isolate and identify of α-glucosidase inhibitor from Aspergillus terreus F38 by liquid fermentation. The mycelium extract of A. terreus F38showed strong activity against α-glucosidase with IC 50 value of 9.65 μg/mL. Separation and purification of mycelium ectract yielded compound I (Butyrolactone III). The structure was establish on the basis of spectral analysis, according to the data obtained by NMR and LCMS-MS experiments. Compound I showed potential activity against α-glucosidase with IC 50 value of 13.87 μg/mL. Therefore, the metabolites from A . terreus F38 can be used as lead compound to design potent α-glucosidase inhibitory agents. |
| Databáze: | OpenAIRE |
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