Auxiliary-Directed C(sp3 )−H Arylation by Synergistic Photoredox and Palladium Catalysis

Autor:	David W. Lupton, Anastasios Polyzos, Milena L. Czyz
Rok vydání:	2017
Předmět:	Oxidative cyclization 010405 organic chemistry Chemistry Radical Organic Chemistry High selectivity chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Nickel Organic chemistry Palladium
Zdroj:	Chemistry - A European Journal. 23:14450-14453
ISSN:	0947-6539
DOI:	10.1002/chem.201704045
Popis:	Herein we describe the auxiliary-directed arylation of unactivated C(sp3 )-H bonds with aryldiazonium salts, which proceeds under synergistic photoredox and palladium catalysis. The site-selective arylation of aliphatic amides with α-quaternary centres is achieved with high selectivity for β-methyl C(sp3 )-H bonds. This operationally simple method is compatible with carbocyclic amides, a range of aryldiazonium salts and proceeds at ambient conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a6e46a447f575bf2780173c289599f96 https://doi.org/10.1002/chem.201704045 Zobrazit plný text záznamu Plný text ve formátu PDF