| Popis: |
A polymer-drug device with two polymers is prepared and tested in in-vitro tests. The device consists of a core obtained by dispersing the drug in Eudragit as polymer and of a shell made of an erodible polymer. The drug chosen in the paper is Sulfanilamide, and the shell is made of “Gelucire”. When in contact with synthetic gastric liquid, these types of dosage forms are able to deliver the drug with a constant rate throughout the whole process. Moreover, the value of this rate of drug delivery is inversely proportional to the thickness of the shell. Some parameters, as the temperature of liquid Gelucire and the time of contact, are of interest for controlling the thickness of the shell. |
