Time-to-event modelling of effect of codrituzumab on overall survival in patients with hepatocellular carcinoma
Autor: | Ghassan K. Abou-Alfa, Takehiko Kawanishi, Norihisa Ohishi, Mikiko Nakamura, Chao Xu, Ya-Chi Chen, Ruey-min Lee, Satofumi Iida, Toshihiko Ohtomo, Cheikh Diack |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pharmacology Oncology Drug medicine.medical_specialty business.industry medicine.drug_class media_common.quotation_subject Logistic regression medicine.disease Monoclonal antibody Clinical trial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Pharmacokinetics 030220 oncology & carcinogenesis Internal medicine Hepatocellular carcinoma medicine Overall survival Pharmacology (medical) business media_common |
Zdroj: | British Journal of Clinical Pharmacology. 84:944-951 |
ISSN: | 0306-5251 |
DOI: | 10.1111/bcp.13530 |
Popis: | Aims Codrituzumab (GC33) is a recombinant, humanized mAb that binds to glypican-3 (GPC3), an oncofetal protein highly expressed in hepatocellular carcinoma (HCC). This investigation aimed to identify clinically relevant factors that may affect the overall survival (OS) in HCC patients treated with codrituzumab and to quantitatively annotate their effects. Methods Codrituzumab exposure was estimated by a population pharmacokinetics model with a nonlinear elimination pathway. Analysis of OS was performed using a time-to-event model in 181 patients with advanced HCC. The model was tested with the addition of various covariates, including levels of immune biomarkers, such as CD16 (measured in terms of molecules of equivalent soluble fluorophore; CD16MESF ) and CD4, codrituzumab exposure and potential prognostic biomarkers of HCC such as baseline tumour size and soluble GPC3. Results The time-to-event model estimated a prolonged OS (>3 months) in patients with codrituzumab exposure of ≥230 μg ml-1 and high CD16MESF level (>5.26 × 105 MESF at least). The Weibull model was selected as the base hazard model. The baseline tumour size was included in the hazard model as a parameter independent of the drug effect. A logistic model was applied to explain the effects of drug exposure and CD16MESF level. Conclusions The final model indicates that adequate drug exposure plus a favourable immune environment are associated with prolonged OS. This quantitative model should be further validated with emerging data so as to guide study design in future clinical trials. |
Databáze: | OpenAIRE |
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