The Design and Synthesis of Selective Prostaglandin Analogs As Bone Anabolic Agents for the Potential Treatment of Osteoporosis

Autor:	Michelle Jeanine Dirr, Glen E. Mieling, Wos John August, Mark Walden Lundy, Michele Elaine Soehner, David Lindsey Soper, Biswanath De, Mitchell Anthony Delong, Wang Yili
Rok vydání:	2002
Předmět:	Prostaglandin analog Chemistry In vivo Osteoporosis Ovariectomized rat medicine Pharmacology Prostaglandin receptor medicine.disease Bone volume Anabolic Agents In vitro
Zdroj:	Advances in Experimental Medicine and Biology ISBN: 9781461349600
DOI:	10.1007/978-1-4615-0193-0_46
Popis:	A series of prostaglandins selective for the human FP receptor have been synthesized and evaluated as potential therapeutics for the treatment of osteoporosis. The compounds proved to be potent (nanomolar binding affinity) and selective (>100x) ligands for the human FP receptor in vitro, and increased bone volume in the ovariectomized rat in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a5e96b8900fd1dc40cf723a3965e7558 https://doi.org/10.1007/978-1-4615-0193-0_46 Zobrazit plný text záznamu