| Autor: |
Nataliya Piriatinskaa, Dmytro Butov, Tatiana Butova, Mykhailo Kuzhko |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Tuberculosis. |
| DOI: |
10.1183/1393003.congress-2017.pa3035 |
| Popis: |
Background: To study the association between IL-2, IL-4 gene polymorphisms and pulmonary MDRTB. Methods: The study comprised 170 individuals in Ukraine including 74 patients MDRTB (group1),66 patients without–MDRTB(group2) and 30 healthy donors(group3).Serum levels of cytokines IL-2 and IL-4(pg/L)were evaluated by ELISA. Two polymorphic variants were examined:T-330G promoter region of IL-2 and C-589T–IL-4genes. Results: In the 1 group the levels of IL-4 and IL-2 were 7.96±0.29 and 39.34±1.14,2nd–11.29±0.35 and 36.20±0.89 while in 3rd–29.99±1.27 and 21.60±0.80 respectively (p Conclusion: Compared to healthy controls patients with tuberculosis had significantly lower levels of serum IL-4 and high - IL-2. This coincided with greater frequency of HeG in 1group and MG in 2group polymorphisms C-589T and T-330G genes of IL-4 and IL-2. Further studies are warranted whether higher rate of MDRTB has a causal immunogenetic relationship to polymorphism of genes encoding for IL-2 and IL-4 than patients without MDRTB. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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