ChemInform Abstract: Synthesis of Novel Thiol-Reactive Amphiphilic Lipids Based on Cholesterol for Protein-Liposome Coupling

Autor:	Thomas Fichert, Jörg Kley, Ulrich Massing
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Liposome Cholesterol General Medicine Combinatorial chemistry Coupling (electronics) chemistry.chemical_compound chemistry Covalent bond Amphiphile Thiol lipids (amino acids peptides and proteins) Ethylene glycol Alkyl
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199827287
Popis:	The synthesis of a series of coupling lipids designed for covalently linking proteins to liposomes is described. The new compounds have in common a cholesterylsuccinyl unit as a lipid anchor and a thiol-reactive maleimidobenzoyl unit which are linked by alkyl or (poly)ethylene glycol spacers that differ in length and polarity.
Databáze:	OpenAIRE
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