Diagnostic and treatment algorithm for different phenotypes of chronic rhinosinusitis with nasal polyps

Autor:	L.E. Gaganov, M. E. Dyneva, E L Savlevich, V.I. Egorov, A.N. Gerasimov, O M Kurbacheva
Rok vydání:	2019
Předmět:	medicine.medical_specialty Chronic rhinosinusitis business.industry Medicine Nasal polyps General Medicine business medicine.disease Phenotype Dermatology
Zdroj:	Russian Journal of Allergy. 16:50-60
ISSN:	2686-682X 1810-8830
Popis:	Chronic rhinosinusitis with nasal polyps (CRSwNP) may vary in clinical manifestations and can often be associated with a number of comorbid diseases. For a practitioner it is important to forecast the development of the disease, evaluate the risk of relapse and select the most efficient method of treatment in each clinical case. At present, there are no standardized and validated diagnostic biomarkers that could be used as predictors of CRSwNP clinical course. Purpose of the study: to develop diagnostic and treatment algorithm for varies CRSwNP phenotypes based on clinical and laboratory parameters. Materials and methods, CRSwNP patients were split into 3 groups: group 1 - CRSwNP without allergy and asthma; group 2 - CRSwNP with allergic rhinitis and/or allergic asthma; group 3 - CRSwNP with non-allergic asthma. All patients were subjected to nasal cavity endoscopy and nasal polyps biopsy, allergological examination, histological analysis of polyp stroma to detect the leukocytes infiltration and eosinophil-neutrophil index (ENI). Results, CRSwNP phenotypes show significant difference in clinical manifestations of rhinosinusitis (p
Databáze:	OpenAIRE
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