Chemical synthesis of a polymerizable bis-substituted phosphoethanolamine

Autor:	David F. O'Brien, Youn-Sik Lee, Warunee Srisiri
Rok vydání:	1995
Předmět:	Acylation Hydrolysis chemistry.chemical_compound Chemistry Yield (chemistry) Organic Chemistry Drug Discovery Organic chemistry Ether Lewis acids and bases Biochemistry Chemical synthesis Catalysis
Zdroj:	Tetrahedron Letters. 36:8945-8948
ISSN:	0040-4039
DOI:	10.1016/0040-4039(95)01930-g
Popis:	The first chemical synthesis of a 1,2-bis-substituted polymerizable-sn-glycerol-3-phosphoethanolamine is reported. The synthetic approach utilizes the preparation of 1,2-bis(16-methy 1-2,4-(E,E)-octadecadienoyl)-3-(4-methoxybenzyl)-sn-glycerol via the acylation of 3-(4-methoxybenzyl)-sn-glycerol with 16-methyl-2,4-(E,E)-octadecadienoic acid. The deprotection of the 4-methoxybenzyl ether group is accomplished in high yield via Lewis acid catalyzed hydrolysis at −78°C. The final step is the phosphorylation of this 1,2-bis(dienoyl)-sn-glycerol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a5108e28af5246f1128c64715dc59892 https://doi.org/10.1016/0040-4039(95)01930-g Zobrazit plný text záznamu Full Text from ScienceDirect