| Autor: |
Daniela Rozkova, Anna Sediva, Veronika Skalická, V. Budinsky, Petr Pohunek, E. Vernerova, Jana Kayserova, I. Zentsova-Jaresova, Jana Kopecka, Radek Spisek |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology. 75:305-313 |
| ISSN: |
0300-9475 |
| DOI: |
10.1111/j.1365-3083.2011.02649.x |
| Popis: |
Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and in controls. Plasmacytoid and four distinct subsets of myeloid DCs [characterized by the expression of blood dendritic cell antigen (BDCA)-1+ and -3+ and CD16 positivity or negativity] were detected in both tested compartments. We further evaluated the expression of C-type lectins [mannose receptor (MR), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and dendritic and epithelial cells (DEC)-205] relevant to the pathogenesis of asthma. Interestingly, we found a selective increase in the frequency of myeloid DC-expressing BDCA-3 and MR particularly in BALF from allergic patients. Specific and highly statistically significant increase in BDCA-3+ and/or MR+ DCs brings a novel characteristic to BAL analysis in allergic patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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