Mechanistic studies in the chemistry of urea. Part 2. Reaction with benzil, 4,4′-dimethylbenzil, and 4,4′-dimethoxybenzil

Autor:	Elizabeth Leitch, Anthony R. Butler
Rok vydání:	1977
Předmět:	chemistry.chemical_compound chemistry Diol Urea Organic chemistry Benzil Medicinal chemistry
Zdroj:	J. Chem. Soc., Perkin Trans. 2. :1972-1976
ISSN:	1364-5471 0300-9580
DOI:	10.1039/p29770001972
Popis:	Urea and N-methylurea react with benzil and substituted benzils in alkaline conditions to form 5,5-diphenylhydantoins, or the appropriately substituted compounds. The mechanism of reaction is rate-determining attack by the urea anion on benzil, rapid cyclisation, and slow rearrangement. The mechanism was deduced from a kinetic study, With NN′-dimethylurea the product is a diol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a4d4ff0d3409b4b0c0afa0401489255f https://doi.org/10.1039/p29770001972 Zobrazit plný text záznamu