An improved synthesis of substituted benzo[b]thiophen-2-carboxylic acids and related acids

Autor:	K. Clarke, N. B. Chapman, P. M. Chakrabarti
Rok vydání:	1969
Předmět:	Oxidative cyclization Ethanol Chemistry Organic Chemistry chemistry.chemical_element Iodine Biochemistry chemistry.chemical_compound Yield (chemistry) Drug Discovery polycyclic compounds Carbon tetrachloride Chlorine Organic chemistry Titration
Zdroj:	Tetrahedron. 25:2781-2785
ISSN:	0040-4020
DOI:	10.1016/0040-4020(69)80021-9
Popis:	The oxidative cyclization of β-Aryl-α-mercaptoacrylic acids with chlorine in dry carbon tetrachloride rapidly gives the corresponding benzo[ b ]thiophen-2-carboxylic acids in high yield. This process is a considerable improvement on processes previously reported. The purity of the crude β-aryl-α-mercaptoacrylic acids can be determined by titration with iodine in ethanol and thus the crude intermediates can be cyclized without further purification by use of the calculated amount of chlorine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a437f9555a3946953d59c5d9e884d7d2 https://doi.org/10.1016/0040-4020(69)80021-9 Zobrazit plný text záznamu