| Autor: |
Jennifer A Juno, Allen C. Cheng, Stephen J. Kent, Steven Y. C. Tong, Katherine Bond, Thi H. O. Nguyen, Jennifer R. Habel, Hui-Fern Koay, Jennifer Audsley, Kevin J. Selva, Florian Krammer, Adam K. Wheatley, Wuji Zhang, Kanta Subbarao, Clare Whitehead, Suellen Nicholson, Xiaoxiao Jia, Hayley A McQuilten, Katherine Kedzierska, Amy A Chung, Luca Hensen, Kathleen M. Wragg, Lilith F. Allen, Natasha E Holmes, Fiona L James, Ebene R. Haycroft, Louise C. Rowntree, Hyon-Xhi Tan, Jessica A. Neil, Gabrielle Pell, Jason A Trubiano, Timon Damelang, Claire L. Gordon, Olivia C Smibert, Irani Thevarajan, Justin T Denholm, Dale I. Godfrey, Fatima Amanat, Lukasz Kedzierski, Carolien E. van de Sandt, Martha Lappas, Brendon Y. Chua, Deborah A Williamson |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Although pregnancy poses a greater risk for severe COVID-19, the underlying immunological changes associated with SARS-CoV-2 infection during pregnancy are poorly understood. We defined immune responses to SARS-CoV-2 in pregnant and non-pregnant women during acute and convalescent COVID-19 up to 258 days post symptom onset, quantifying 217 immunological parameters. Additionally, matched maternal and cord blood were collected from COVID-19 convalescent pregnancies. Although serological responses to SARS-CoV-2 were similar in pregnant and non-pregnant women, cellular immune analyses revealed marked differences in key NK cell and unconventional T cell responses during COVID-19 in pregnant women. While NK, γδ T cells and MAIT cells displayed pre-activated phenotypes in healthy pregnant women when compared to non-pregnant age-matched women, activation profiles of these pre-activated NK and unconventional T cells remained unchanged at acute and convalescent COVID-19 in pregnancy. Conversely, activation dynamics of NK and unconventional T cells were prototypical in non-pregnant women in COVID-19. In contrast, activation of αβ CD4+ and CD8+ T cells, T follicular helper cells and antibody-secreting cells was similar in pregnant and non-pregnant women with COVID-19. Elevated levels of IL-1β, IFN-γ, IL-8, IL-18 and IL-33 were also found in pregnant women in their healthy state, and these cytokine levels remained elevated during acute and convalescent COVID-19. Collectively, our study provides the first comprehensive map of longitudinal immunological responses to SARS-CoV-2 infection in pregnant women, providing insights into patient management and education during COVID-19 pregnancy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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