A comparison of prostate cancer bone metastases on 18F-Sodium Fluoride and Prostate Specific Membrane Antigen (18F-PSMA) PET/CT: Discordant uptake in the same lesion
| Autor: | Stephen Adler, Yolanda McKinney, Joanna H. Shih, Esther Mena, Anna Couvillon, Liza Lindenberg, Baris Turkbey, Martin G. Pomper, Peter L. Choyke, William L. Dahut, Ravi A. Madan, Ronnie C. Mease, Ethan Bergvall, James L. Gulley, Adam G. Sowalsky, Sherif Mehralivand, Janet F. Eary, Stephanie Harmon |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty Genitourinary system business.industry Concordance Cancer medicine.disease 030218 nuclear medicine & medical imaging 3. Good health Bone remodeling Lesion 03 medical and health sciences Prostate cancer 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Glutamate carboxypeptidase II medicine medicine.symptom business Cancer Imaging Program |
| Zdroj: | Oncotarget. 9:37676-37688 |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.26481 |
| Popis: | // Stephanie A. Harmon 1, 2 , Esther Mena 2 , Joanna H. Shih 3 , Stephen Adler 1, 2 , Yolanda McKinney 2 , Ethan Bergvall 2 , Sherif Mehralivand 2 , Adam G. Sowalsky 4 , Anna Couvillon 5 , Ravi A. Madan 5 , James L. Gulley 5 , Janet Eary 6 , Ronnie C. Mease 7 , Martin G. Pomper 7 , William L. Dahut 5 , Baris Turkbey 2 , Liza Lindenberg 2 and Peter L. Choyke 2 1 Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA 2 Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA 3 Biometric Research Branch, National Cancer Institute, NIH, Bethesda, MD, USA 4 Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA 5 Genitourinary Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD, USA 6 Cancer Imaging Program, National Cancer Institute, NIH, Rockville, MD, USA 7 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA Correspondence to: Stephanie A. Harmon, email: stephanie.harmon@nih.gov Keywords: prostate cancer; bone metastases; sodium fluoride; prostate specific membrane antigen; spatial analysis Received: October 01, 2018 Accepted: December 04, 2018 Published: December 28, 2018 ABSTRACT Purpose: Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of 18 F-NaF PET/CT and 18 F-PSMA-targeted PET/CT within prostate cancer bone metastases. Methods: Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT ( 18 F-DCFBC or 18 F-DCFPyL) and 18 F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization. Overlap volume was correlated with uptake characteristics and disease status. Results: The study included 149 lesions in 19 patients. Qualitatively, lesions exhibited a heterogeneous range of spatial concordance between PSMA and NaF uptake from completely matched to completely discordant. Quantitatively, overlap volume decreased as a function of tracer intensity. and disease status, where lesions from patients with castration-sensitive disease showed higher spatial concordance while lesions from patients with castration-resistant disease demonstrated more frequent spatial discordance. Conclusion: As metastatic prostate cancer progresses from castration-sensitive to castration-resistant, greater discordance is observed between NaF PET and PSMA PET uptake. This may indicate a possible phenotypic shift to tumor growth that is more independent of bone remodeling via osteoblastic formation. |
| Databáze: | OpenAIRE |
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