The association of the TP53 polymorphisms Pro72Arg and C(−594)CC with diabetic polyneuropathy in Russian Muscovites with type 1 diabetes mellitus

Autor:	Nosikov Vv, I. A. Strokov, T. N. Soluyanova, Chudakova Da, N. Yu. Yakunina, G. N. Svetlova, Alexey Nikitin, E. V. Spitsina
Rok vydání:	2007
Předmět:	Type 1 diabetes medicine.medical_specialty endocrine system diseases business.industry Biophysics nutritional and metabolic diseases medicine.disease Lower risk Genotype frequency Endocrinology Structural Biology Diabetic polyneuropathy Internal medicine Genotype Medicine Allele business
Zdroj:	Molecular Biology. 41:901-905
ISSN:	1608-3245 0026-8933
DOI:	10.1134/s0026893307060052
Popis:	The allele and genotype frequency distributions of the Pro72Arg and C(−594)CC polymorphisms of the TP53 gene were studied in type 1 diabetes mellitus (T1DM) patients, ethnic Russians from Moscow, with a T1DM record of no more than 5 years and diabetic polyneuropathy (DPN) or a T1DM record of more than 10 years but without DPN. The Pro72Arg polymorphism was associated with DPN, a higher risk of DPN being determined by allele Arg (OR = 1.96, CI 1.32−2.90) and genotype Arg/Arg (OR = 2.14, CI 1.23−3.73). Allele Pro was associated with a lower risk of DPN (OR = 0.51, CI 0.34−0.76). No association with DPN was observed for the C(−594)CC polymorphism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3af8fee2100ab66a085d63cfceac837 https://doi.org/10.1134/s0026893307060052 Zobrazit plný text záznamu Full text from SpringerLink