The Importance of Altered Hematopoietic Microenvironmental Regulation in Chronic Myeloproliferative Disorders
| Autor: | Ahmad Reza Rahnemoon |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Stromal cell Cellular differentiation Biology Blood cell Endothelial stem cell Extracellular matrix 03 medical and health sciences Haematopoiesis 030104 developmental biology medicine.anatomical_structure Immunology medicine Cancer research Stem cell Induced pluripotent stem cell |
| Zdroj: | Journal of Hematology & Thromboembolic Diseases. |
| ISSN: | 2329-8790 |
| Popis: | Normal hematopoiesis depends on critical interactions that occur between stem cells and their microenvironment. This microenvironment is a complex meshwork composed of growth factors, stromal cells, and the extracellular matrix. Pluripotent Stem Cells (PSCs) are the stem cells which present in Chronic Myeloproliferative Disorders (CMPD) to have self-renewal capacity and towards differentiated cells in blood cells lineages. When the process of these stem cells become deregulated, neoplasm can result with possibly several mutations as well as the alterations in the control of growth factors and meanwhile disrupt the normal HSC function and blood cell production. Thus, these interactions must important in the pathogenesis and clinical expression of hematopoietic malignancies in humans. Here, I review the leukemic hematopoietic microenvironment and the genetic alterations as well. |
| Databáze: | OpenAIRE |
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