Radiation Synthesis of pH-Sensitive Hydrogels From Carboxymethyl Cellulose/Poly(ethylene Oxide) Blends as Drug Delivery Systems

Autor:	Faten I. Abu-El Fadle, Abdel Wahab M. El-Naggar, Horia M. Nizam El-Din
Rok vydání:	2013
Předmět:	Thermogravimetric analysis Materials science Polymers and Plastics Ethylene oxide General Chemical Engineering technology industry and agriculture Oxide macromolecular substances complex mixtures Analytical Chemistry Carboxymethyl cellulose chemistry.chemical_compound Differential scanning calorimetry chemistry Chemical engineering Self-healing hydrogels Polymer chemistry Drug delivery medicine Swelling medicine.symptom medicine.drug
Zdroj:	International Journal of Polymeric Materials. 62:711-718
ISSN:	1563-535X 0091-4037
DOI:	10.1080/00914037.2013.769231
Popis:	Gamma irradiation was used to prepare hydrogels from carboxymethyl cellulose (CMC) and poly(ethylene oxide) (PEO) blends in the form of films. The hydrogels were characterized by IR spectroscopy, differential scanning calorimetry, thermogravimetric analysis, mechanical testing, and scanning electron microscopy. The swelling in different buffers of different pH values was also studied. The results indicated the formation of network structure and that the swelling of hydrogels is thermo- and pH-sensitive. The CMC/PEO hydrogels were evaluated for the possible use in drug delivery field, in which the release profile of ketoprofen, as a drug model was investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a318c2ed20f0e8605a20f8b319ef5de0 https://doi.org/10.1080/00914037.2013.769231 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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