Changes in activity of hippocampus creatine kinase under circadian rhythm disorders
| Autor: | Matrona Chachua, Zurab Kuchukashvili, K. O. Menabde, Natalia Dachanidze, Nana Koshoridze, George Burjanadze |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty biology Physiology Hippocampus Mitochondrion Hippocampal formation Creatine Enzyme assay chemistry.chemical_compound Enzyme Endocrinology chemistry Physiology (medical) Internal medicine biology.protein medicine Creatine kinase Circadian rhythm Ecology Evolution Behavior and Systematics |
| Zdroj: | Biological Rhythm Research. :1-13 |
| ISSN: | 1744-4179 0929-1016 |
| DOI: | 10.1080/09291016.2014.888172 |
| Popis: | We have studied the influences that prolonged isolation and disruption of the circadian cycle have on behavioral activity and hormonal status among animals. It has been showed that such conditions result in development of stress, and decreases occur in the activity of both isoforms of rat hippocampus creatine kinase (CK). We have established kinetic parameters (Vmax, Km) of this hippocampal enzyme and the nature of the modifications produced by the protocol. It has been suggested that prolonged isolation and disrupted natural circadian cycle result in lower CK-BB activity in animals due to structural changes in the enzyme and a decrease in ATP and creatine substrates. Lowered enzyme activity is accompanied by an accumulation of Ca2+ ions in the cell, and this might decrease activity of plasma membrane and mitochondrial Ca-ATPase. |
| Databáze: | OpenAIRE |
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