A tomato stem cell extract, containing antioxidant compounds and metal chelating factors, protects skin cells from heavy metal-induced damages
| Autor: | Jacqueline Hill, Fabio Apone, Simone Gibertoni, Irene Monoli, Ani Barbulova, Francesco de Laurentiis, Antonietta Carola, Stefania Arciello, Annalisa Tito, Marida Bimonte, Gabriella Colucci |
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| Rok vydání: | 2011 |
| Předmět: |
Aging
Plant stem cell Antioxidant Chemistry DNA repair medicine.medical_treatment Pharmaceutical Science Metal toxicity Human skin Dermatology medicine.disease_cause Colloid and Surface Chemistry Biochemistry Chemistry (miscellaneous) Drug Discovery Botany medicine Collagenase Stem cell Oxidative stress medicine.drug |
| Zdroj: | International Journal of Cosmetic Science. 33:543-552 |
| ISSN: | 0142-5463 |
| DOI: | 10.1111/j.1468-2494.2011.00668.x |
| Popis: | Heavy metals can cause several genotoxic effects on cells, including oxidative stress, DNA sequence breakage and protein modification. Among the body organs, skin is certainly the most exposed to heavy metal stress and thus the most damaged by the toxic effects that these chemicals cause. Moreover, heavy metals, in particular nickel, can induce the over-expression of collagenases (enzymes responsible for collagen degradation), leading to weakening of the skin extracellular matrix. Plants have evolved sophisticated mechanisms to protect their cells from heavy metal toxicity, including the synthesis of metal chelating proteins and peptides, such as metallothioneins and phytochelatins (PC), which capture the metals and prevent the damages on the cellular structures. To protect human skin cells from heavy metal toxicity, we developed a new cosmetic active ingredient from Lycopersicon esculentum (tomato) cultured stem cells. This product, besides its high content of antioxidant compounds, contained PC, effective in the protection of skin cells towards heavy metal toxicity. We have demonstrated that this new product preserves nuclear DNA integrity from heavy metal damages, by inducing genes responsible for DNA repair and protection, and neutralizes the effect of heavy metals on collagen degradation, by inhibiting collagenase expression and inducing the synthesis of new collagen. |
| Databáze: | OpenAIRE |
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