Effects of social isolation and environmental enrichment on atherosclerosis in ApoE−/−mice

Autor:	Göran Bergström, Irene J. Andersson, Evelina Bernberg, Maria E. Johansson, Li-Ming Gan, Andrew S. Naylor
Rok vydání:	2008
Předmět:	medicine.medical_specialty Environmental enrichment Endocrine and Autonomic Systems Physiology medicine.medical_treatment Biology Behavioral Neuroscience Psychiatry and Mental health chemistry.chemical_compound Neuropsychology and Physiological Psychology Cytokine Endocrinology medicine.anatomical_structure Blood pressure chemistry Corticosterone Internal medicine medicine.artery Heart rate medicine Thoracic aorta Social isolation medicine.symptom Artery
Zdroj:	Stress. 11:381-389
ISSN:	1607-8888 1025-3890
Popis:	Social support and a stimulating environment have been suggested to reduce stress reactions and cardiovascular risk. The aim of this study was to assess the role of environmental enrichment and social interaction for development of atherosclerosis in atherosclerosis prone mice. Male ApoE-/- mice were divided into four groups and followed during 20 weeks: (i) enriched environment (E, n=12), (ii) deprived environment (ED, n=12), (iii) enriched environment with exercise (E-Ex, n=12) and (iv) socially deprived by individual housing (SD, n=10). Plasma lipid and cytokine concentrations were measured. Atherosclerosis was quantified in cross-sections of innominate artery and en face in thoracic aorta. Plaque area was significantly increased in SD mice in the innominate artery (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a27f7678246efa0d7adfa0c7545820e9 https://doi.org/10.1080/10253890701824051 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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