Marked hyperferritinemia as indicator of a reactive hemophagocytotic syndrome
| Autor: | A. Engel, J. Brunner, R. Dinser |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test Bilirubin business.industry Albumin General Medicine medicine.disease Gastroenterology Ferritin chemistry.chemical_compound medicine.anatomical_structure chemistry Cervical lymph nodes Internal medicine Biopsy medicine biology.protein Prednisolone Polyarthritis Hemophagocytosis business medicine.drug |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 128:1282-1284 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2003-39796 |
| Popis: | HISTORY AND ADMISSION FINDINGS A 17-year-old girl with a history of a polyarthritis of unknown etiology was admitted because of acute fever and general weakness. There were palpable cervical lymph nodes and her body temperature was 39.5 degrees C. INVESTIGATIONS GOT was raised to 282 U/1, GPT to 266 U/l lactate dehydrogenase to 1275 U/I and bilirubin to 0.6 mg/dl. The Quick value was 67%, albumin 28 mg/dl. White cell count was decreased to 1700/microl, with 43% granulocytes, 39% lymphocytes, 17% monocytes. Platelet count was 64,000/microl. Ultrasound revealed splenomegaly. Ferritin was markedly raised to 11,860 ng/ml (normal up to 150 ng/ml). An epstein-barr-virus infection was found. THERAPY AND CLINICAL COURSE Suspecting a reactive hemophagocytosis syndrome, she was treated with prednisolone (2 mg/kg). The diagnosis was confirmed by a bone marrow aspirate. The patient's condition and laboratory values improved rapidly. CONCLUSION Markedly increased ferritin levels in a clinically septic patient with an underlying rheumatic disease indicates a hemophagocytotic syndrome. High dosage steroid should be started before there is biopsy confirmation of the disease. |
| Databáze: | OpenAIRE |
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