Oral Precancerous Lesions Show Increased Levels of Glutathione Compared to Cancerous Tissue
| Autor: | Deshmukh Revati, Hingad Nupur, Goyal Garish, Khan Shahida, Hegde Mahabaleshwar |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Nutrition and Dietetics Total glutathione DNA damage Public Health Environmental and Occupational Health Endogeny Oxidative phosphorylation Glutathione Biology female genital diseases and pregnancy complications Malignant transformation chemistry.chemical_compound chemistry Cancer research medicine Malignant cells Mitosis Food Science |
| Zdroj: | Current Nutrition & Food Science. 6:223-226 |
| ISSN: | 1573-4013 |
| DOI: | 10.2174/157340110792389109 |
| Popis: | Malignant cells are known to contain high amounts of glutathione, a potent endogenous anti-oxidant, which is believed to contribute to their increased rate of mitosis and resistance to chemo and radiotherapies. But there is very little information as to the levels of glutathione in precancerous cells. In the present study, it was noted that the concentrations of total glutathione is significantly higher in human precancerous cells compared to cancerous cells. The higher amounts of glutathione noted in precancerous cells could be a protective mechanism adopted to prevent oxidative stress-induced DNA damage that aids malignant transformation process. |
| Databáze: | OpenAIRE |
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