Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil
| Autor: | Viorica Meltzer, Cornel Munteanu, Gabriel Munteanu, Andreea Dana Neacsu, Elena Pincu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Materials Science (miscellaneous) Process Chemistry and Technology General Engineering Solid-state Uracil Beta-Cyclodextrins General Chemistry General Medicine 010402 general chemistry 01 natural sciences Combinatorial chemistry General Biochemistry Genetics and Molecular Biology 0104 chemical sciences chemistry.chemical_compound chemistry Fluorouracil Materials Chemistry medicine General Pharmacology Toxicology and Pharmaceutics Inclusion (mineral) medicine.drug |
| Zdroj: | Revista de Chimie. 68:2756-2760 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.17.12.5971 |
| Popis: | The objective of the present work was to obtain and evaluate the solid inclusion complexes of a-, b-cyclodextrins and hydroxypropyl-a-, hydroxypropyl-b-cyclodextrins derivatives with uracil (U) and anti-cancer agent 5-fluorouracil (5FU). The thermogravimetry (TG), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy in attenuated total reflectance mode (FTIR-ATR) and scanning electron microscopy (SEM) were used to characterize these inclusion compounds. New information on the physicochemical behavior of these solid state complexes synthesized by melting in solution was obtained. Corelating the experimental data we found that the complexation occurs for each host:guest system thus, the preparation method exhibited a real efficiency to interaction achievements. The inclusion capability and the thermal stability of the studied complexes were due to both the flexibility and the size of the cyclodextrin ring as well the stereoelectronic effect of the U or 5FU molecule. We appreciated that the complexes between U or 5FU with 2-hydroxypropyl derivatives of a- and b- CD have the largest content of guest and are the most stable. The obtained results could be useful in formulation of the pharmaceutical products and also in drug delivery. |
| Databáze: | OpenAIRE |
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