| Autor: |
Chao Wang, Shenghao Wang, Lanlan Zhang, Leipeng Xie, Lei Zhao, Chun Luo, Linping Mu, Xiuguang Wang |
| Rok vydání: |
2021 |
| DOI: |
10.21203/rs.3.rs-346280/v1 |
| Popis: |
An intermolecular syn-1,2-arylamination of unactivated alkenes with arylboronic acids and O-benzoylhydroxylamine electrophiles has been developed with Ni(II) catalyst. The cleavable bidentate picolinamide directing group facilitated formation of stabilized 4-, 5- or 6-membered nickelacycles and enabled the difunctionalization of diverse alkenyl amines with high levels of regio-, chemo- and diastereocontrol. This general and practical protocol was compatible with broad substrate scope and high functional group tolerance. The utility of this method was further demonstrated by the site-selective late-stage modification of pharmaceutical agents. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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