The Norwegian Colorectal Cancer Prevention (NORCCAP) Screening Study
| Autor: | Geir Hoff, G. Gondal, Michael Bretthauer, Tor J. Eide, B. Hofstad, Tom Grotmol |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Randomization medicine.diagnostic_test business.industry Population Gastroenterology Colonoscopy Sigmoidoscopy digestive system diseases law.invention Clinical trial Randomized controlled trial law Internal medicine medicine education business Prospective cohort study Mass screening |
| Zdroj: | Scandinavian Journal of Gastroenterology. 38:635-642 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/00365520310003002 |
| Popis: | Background: Randomized controlled trials of sufficient power testing the long-term effect of screening for colorectal neoplasia only exist for faecal occult blood testing (FOBT). There is indirect evidence that flexible sigmoidoscopy (FS) may have a greater yield. The aim of this study was to determine the diagnostic yield of screening with FS or a combination of FS and FOBT in an average-risk population in an urban and combined urban and rural population in Norway. Methods: 20,780 men and women (1:1), aged 50-64 years, were invited for once-only screening (FS only or a combination of FS and FOBT (1:1)) by randomization from the population registry. A positive FS was defined as a finding of any neoplasia or any polyp S 10 r mm. A positive FS or FOBT qualified for colonoscopy. Results: Overall attendance was 65%. Forty-one (0.3%) cases of CRC were detected. Any adenoma was found in 2208 (17%) participants and 545 (4.2%) had high-risk adenomas. There was no difference in diagnostic yield between the ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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