| Autor: |
Antoine A. Noujaim, S.N. Muddukrishna, A. Chen, Thomas R. Sykes |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Applied Radiation and Isotopes. 45:293-299 |
| ISSN: |
0969-8043 |
| DOI: |
10.1016/0969-8043(94)90042-6 |
| Popis: |
A method of quantitating stannous ion [Sn(II)] suitable for radiopharmaceutical kits, based on indirect iodometric titration, is described. The method is based on the oxidation of Sn(II) using a known excess of iodine and the excess unreacted iodine determined using thiosulphate by potentiometric titration. The titration cell is a beaker and the titrations are done conveniently under air using an autotitrator in approx. 4 min. The method is accurate and is linear in the range of approx. 10 μg to approx. 6 mg of Sn(II). Several radiopharmaceutical kits were analysed for their Sn(II) content using the method including those containing antibodies or other proteins. The studies indicate that the procedure is rapid, simple and accurate for routine quantitative estimation of Sn(II) in radiopharmaceutical preparations during development, manufacture and storage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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