Development and Validation of a Quantitative Determination Method for the Antitubercular Drug PBTZ169 in Biological Media

Autor:	L. M. Makarenkova, S. S. Barsegyan, V. V. Chistyakov, E. S. Stepanova
Rok vydání:	2018
Předmět:	0301 basic medicine Pharmacology Drug Detection limit Chromatography Chemistry Calibration curve media_common.quotation_subject Urine Quantitative determination 03 medical and health sciences 030104 developmental biology Blood serum Drug Discovery Perindopril medicine Feces media_common medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 52:248-253
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-018-1801-x
Popis:	An HPLC-MS/MS method for quantitative determination of the new antituberculosis drug PBTZ169 in blood serum, urine, and feces using perindopril as an internal standard was developed and validated. The method was selective, specific, accurate, and precise. Calibration curves were linear in the ranges 2 – 2,000, 5 – 3,000, and 100 – 10,000 ng/mL for blood serum, urine, and feces, respectively, with correlation coefficients >0.99. The detection limits of PBTZ169 were 1, 2.5, and 50 ng/mL for serum, urine, and feces, respectively. The limits of quantitation were 2 ng/mL in serum; 5, urine; and 100, feces.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a06073df4b9240750805e08e5043a0ca https://doi.org/10.1007/s11094-018-1801-x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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