FRI0453 Hospitalisation and survival analysis in systemic sclerosis patients with concomitant or isolated pulmonary hypertension and interstitial lung disease in the multiethnic scleroderma cohort singapore
| Autor: | S.M.Y. Kua, Maria Noviani, E.L.W. Tay, James Yip, S.C. Ng, A. Lim, Weng Giap Law, A.H.L. Low, J.L. Tan, Gim Gee Teng, Grace Yin Lai Chan, Amelia Santosa, E.S. Seyed |
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| Rok vydání: | 2018 |
| Předmět: |
High-resolution computed tomography
medicine.medical_specialty medicine.diagnostic_test business.industry Interstitial lung disease respiratory system medicine.disease behavioral disciplines and activities Pulmonary hypertension Scleroderma respiratory tract diseases body regions FEV1/FVC ratio Concomitant Internal medicine Cohort medicine business Survival analysis |
| Zdroj: | FRIDAY, 15 JUNE 2018. |
| DOI: | 10.1136/annrheumdis-2018-eular.3185 |
| Popis: | Background Concomitant pulmonary hypertension and interstitial lung disease in systemic sclerosis (SSc-PH-ILD) represents a distinct subpopulation of SSc with poorer prognosis in Western studies. In Asian patients, characterisation of SSc-PH-ILD is still lacking. Objectives To analyse hospital admissions, survival and prognostic markers among SSc patients with PH, ILD or concomitant PH-ILD in the Scleroderma Cohort Singapore. Methods In this study involving 3 tertiary Rheumatology institutions Jan 2008 to , Oct 2016 SSc patients with significant pulmonary involvement were included. ILD was based on high resolution computed tomography and predicted FVC Results Among 490 patients, 92 had ILD, 50 PH and 43 PH-ILD (table 1). Of 93 patients with PH or PH-ILD, 56 were based on echocardiography and 37 on RHC. The 5 year survival was 79%, 87% and 90% in PH, PH-ILD and ILD subgroup, respectively (figure 1). In multivariable analysis, PH was significantly associated with 2.8-fold increased risk of death. Male gender, malabsorption, digital ulcerations and renal crisis were also significantly associated with mortality (table 2). No significant difference in hospital admissions/year among different subgroups. Increased hospital admissions were associated with renal crisis, right heart failure and use of PH medications. Conclusions Compared to those with ILD or PH-ILD, SSc-PH patients had increased mortality, but not hospitalisation rates. This could be due to small sample size or short follow up duration. We identified risk factors associated with worse outcomes in SSc patients with significant pulmonary involvement. Disclosure of Interest None declared |
| Databáze: | OpenAIRE |
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